Paper Number
PO113 

Session
Poster Session

Title
The effects of hemodynamics on the myogenic response of microvessels

Presentation Date and Time
October 12, 2022 (Wednesday) 6:30

Track / Room
Poster Session / Riverwalk A

Authors (Click on name to view author profile)

  1. Giannokostas, Konstantinos (University of Patras, Department of Chemical Engineering)
  2. Marousis, Antonis (University of Patras, Department of Chemical Engineering)
  3. Dimakopoulos, Yiannis (University of Patras, Department of Chemical Engineering)
  4. Tsamopoulos, John (University of Patras, Department of Chemical Engineering)

Author and Affiliation Lines (in printed abstract book)
Konstantinos Giannokostas, Antonis Marousis, Yiannis Dimakopoulos and John Tsamopoulos
Department of Chemical Engineering, University of Patras, Patras, Achaia 26225, Greece

Speaker / Presenter 
Dimakopoulos, Yiannis

Keywords
computational methods; active matter; bio-fluids; biomaterials

Text of Abstract
We propose an advanced fsi model for studying the effects of hemodynamics on the myogenic response of microvessels. The arteriolar tissue is modeled as a two-layer fiber-reinforced hyperelastic material, accounting for active and passive stresses, coupled with the blood/plasma flow in the lumen. Blood in the vessel core is rheologically represented by the thixotropic elasto-viscoplastic (TEVP), and blood plasma in the annular part of the vessel, by the linear Phan-Thien and Tanner (l-PTT) viscoelastic model. The Fähraeus and Fähraeus-Lindqvist effects are accounted for via analytical expressions based on experimental data. We focus on the impact of active tone on the contractile functionality of vascular beds by comparing our results with experimental data in the limit of small intercellular calcium when the passive stresses contribute mainly. We find that an increased intercellular calcium concentration intensifies the active forces and the resistance to arteriole expansion. The active vasodilation produces forces opposing those in passive elastic vessels, maintaining the vascular tone. The circumferential component contributes the most to the stress tensor, while the radial and axial components are notable in passive elastic arterioles only. ---- This work is part of the Research Project “Multiscale modeling for the autoregulation of Microvessels, CARE” which was supported by the Hellenic Foundation for Research and Innovation (H.F.R.I.) under the “1st Call for H.F.R.I. Research Projects to support Faculty members and Researchers and the procurement of high-cost research equipment” (Project No. 81105).