Paper Number
BF21
Session
Biomaterials and Bio-fluid Dynamics
Title
A physiology-based constitutive approach to hemorheology
Presentation Date and Time
October 11, 2022 (Tuesday) 4:45
Track / Room
Track 4 / Michigan AB
Authors
- Javadi, Elahe (Northeastern University, Mechanical and Industrial Engineering)
- Armstrong, Matthew (United States Military Academy, Department of the Army)
- Jamali, Safa (Northeastern University)
Author and Affiliation Lines
Elahe Javadi1, Matthew Armstrong2 and Safa Jamali3
1Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02116; 2Department of the Army, United States Military Academy, New York, NY; 3Northeastern University, Boston, MA
Speaker / Presenter
Javadi, Elahe
Keywords
theoretical methods; computational methods; bio-fluids
Text of Abstract
Blood is considered a complex fluid with a rate and time-dependent response to an applied deformation rate. At low shear rates, the bridging of fibrinogen proteins results in the formation of rouleaux structures manifesting in a large increase in overall viscosity and measurable yield stress. However, these internal flocculated mesostructures are broken down under sufficient shear forces in a dynamical fashion, giving rise to thermokinematic memory formation and thixotropic behavior of the blood. Thus, the rheological behavior of blood and more specifically timescales associated with thixotropic behavior in the blood can be used as a proxy for hematocrit and protein concentration in blood. We combine a series of experimental measurements with in silico flow measurements and present a constitutive model that can predict blood rheology based on the physiological measurement of the blood, namely the hematocrit and fibrinogen concentration. This model is capable of characterizing human blood under steady and transient flows and allows for quantitative descriptions of the hemorheological behavior without requiring experimental interrogation of blood samples.