Paper Number
BB5 

Session
Biomaterials and Biofluid Dynamics

Title
Large amplitude oscillatory shear (LAOS) flow as a metric of comparison for contemporary human blood rheological models

Presentation Date and Time
October 21, 2019 (Monday) 11:30

Track / Room
Track 6 / Room 306B

Authors (Click on name to view author profile)

  1. Armstrong, Matthew J. (United States Military Academy)
  2. Horner, Jeffrey S. (University of Delaware, Chemical and Biomolecular Engineering)
  3. Deegan, Michael (United States Military Academy, Chemistry and Life Science)
  4. Wagner, Norman J. (University of Delaware, Chemical and Biomolecular Engineering)
  5. Beris, Antony N. (University of Delaware, Chemical and Biomolecular Engineering)

Author and Affiliation Lines (in printed abstract book)
Matthew J. Armstrong1, Jeffrey S. Horner2, Michael Deegan3, Norman J. Wagner2, and Antony N. Beris2
1United States Military Academy, West Point, NY 10996; 2Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716; 3Chemistry and Life Science, United States Military Academy, West Point, NY 10996

Speaker / Presenter 
Armstrong, Matthew J.

Text of Abstract
Recent work modeling the rheological behavior of human blood indicates that blood has all of the hallmark features of a complex material, including shear-thinning, viscoelastic behavior, a yield stress and thixotropy. After decades of modeling steady state blood data, and the development of steady state models, like the Casson, Carreau-Yasuda, Herschel-Bulkley, etc. the advancement and evolution of blood modeling to transient flow conditions now has a renewed interest [1,2,5,11]. Using recently collected human blood rheological data we show and compare modeling efforts with several new models including the new modified Horner-Armstrong-Wagner-Beris (mHAWB), the viscoelastic enhanced Modified Delaware Thixotropic Model (MDTM), and more. We will compare the new approaches by ability to predict smalland large amplitude oscillatory shear flow as well as uni-directional oscillatory shear flow. This effort is followed with a discussion of novel transient flow rheological experiments applied to human blood including for model fitting purposes including step-up/step-down, and triangle ramp experiments [7-10]. The family of models that can handle these transient flows involve modifications to the recently published Modified Delaware Thixotropic Model (MDTM), the mHAWB model and the Bautista-Monero-Puig Model (BMP) [1-11]. We fist discuss the development of the scalar, structure parameter evolution models and we compare fitting results with our newly acquired transient blood data to the models [5,11]. We also highlight our novel model fitting procedure by first fitting to steady state, and while keeping the steady state parameters constant fitting the remaining model transient parameters to a series of step up/down in shear rate experiments. With the full set of parameters determined with a global, stochastic optimization algorithm the SAOS, LAOS and unidirectional oscillatory shear flow is predicted and compared to the data. Model efficacy is then compared.