Paper Number
BA15 

Session
Biological and Active Matters

Title
Contemporary modeling and analysis of human blood rheology with recently developed models, experimental and analysis techniques

Presentation Date and Time
October 16, 2018 (Tuesday) 10:15

Track / Room
Track 6 / Tanglewood

Authors (Click on name to view author profile)

  1. Armstrong, Matthew J. (United States Military Academy, Chemistry and Life Science)
  2. Wagner, Norman J. (University of Delaware)
  3. Beris, Antony N. (University of Delaware, Chemical and Biomolecular Engineering)
  4. Horner, Jeffrey S. (University of Delaware, Chemical and Biomolecular Engineering)
  5. Hill, Timothy (United States Military Academy, Chemistry and Life Science)
  6. Keith, Charles (United States Military Academy)

Author and Affiliation Lines (in printed abstract book)
Matthew J. Armstrong1, Norman J. Wagner2, Antony N. Beris2, Jeffrey S. Horner2, Timothy Hill1, and Charles Keith3
1Chemistry and Life Science, United States Military Academy, West Point, NY 10996; 2Chemical and Biomolecular Engineering, University of Delaware, Newark, DE; 3United States Military Academy, Westpoint, NY

Speaker / Presenter 
Keith, Charles

Text of Abstract
Recent work modeling the rheological behavior of blood indicates that blood has all of the hallmark features of a complex material, including shear-thinning, viscoelastic behavior, a yield stress and thixotropy. After decades of modeling steady state blood data, and the development of steady state models, like the Casson, Herschel-Bulkley, etc. the advancement and evolution of blood modeling to transient flow conditions now has a renewed interest. Using recently collected human blood rheological data we show and compare modeling efforts with several new models including the Horner-Armstrong-Wagner-Beris (HAWB), the VE-MDTM, and more. We will compare the new approaches, along with discussion of how we have integrated thixotropic and viscoelastic features for each new model. This is followed with a discussion of novel transient flow rheological experiments applied to human blood including for model fitting purposes including step-up/step-down, sawtooth experiments and Large Amplitude Oscillatory Shear (LAOS) flow. The family of models that can handle these transient flows involve modifications to the recently published Modified Delaware Thixotropic Model (MDTM), the HAWB and the Bautista-Monero-Puig Model (BMP). Lastly we demonstrate a novel approach to analyzing transient blood data by incorporating the novel Series of Physical Phenomena (SPP) framework, and proposed SPP-Lambda. Recent work with blood using LAOS and transient data has shown that its unique rheological signature can be used as a psuedo- “fingerprint”, able to clearly show and delineate elastic and viscous regions of the LAOS cycle. Applying large amplitude oscillatory shear (LAOS) to complex fluids induces nonlinear rheological responses, that, with proper LAOS analysis technique, can be used to sensitively probe the underlying microstructure and its dynamics. This is done with our recently acquired blood data.